The hot gas content of fossil galaxy clusters

We investigate the properties of the hot gas in four fossil galaxy systems detected at high significance in the Planck Sunyaev-Zeldovich (SZ) survey. XMM-Newton observations reveal overall temperatures of kT ~ 5-6 keV and yield hydrostatic masses M500,HE > 3.5 x 10e14 Msun, confirming their nature as bona fide massive clusters. We measure the thermodynamic properties of the hot gas in X-rays (out to beyond R500 in three cases) and derive their individual pressure profiles out to R ~ 2.5 R500 with the SZ data. We combine the X-ray and SZ data to measure hydrostatic mass profiles and to examine the hot gas content and its radial distribution. The average Navarro-Frenk-White (NFW) concentration parameter, c500 = 3.2 +/- 0.4, is the same as that of relaxed `normal' clusters. The gas mass fraction profiles exhibit striking variation in the inner regions, but converge to approximately the cosmic baryon fraction (corrected for depletion) at R500. Beyond R500 the gas mass fraction profiles again diverge, which we interpret as being due to a difference in gas clumping and/or a breakdown of hydrostatic equilibrium in the external regions. Overall our observations point to considerable radial variation in the hot gas content and in the gas clumping and/or hydrostatic equilibrium properties in these fossil clusters, at odds with the interpretation of their being old, evolved and undisturbed. At least some fossil objects appear to be dynamically young.Comment: 4 pages, 2 figures. Accepted for publication in A&

Asymptotic Conformal Yano--Killing Tensors for Schwarzschild Metric

The asymptotic conformal Yano--Killing tensor proposed in J. Jezierski, On the relation between metric and spin-2 formulation of linearized Einstein theory [GRG, in print (1994)] is analyzed for Schwarzschild metric and tensor equations defining this object are given. The result shows that the Schwarzschild metric (and other metrics which are asymptotically ``Schwarzschildean'' up to O(1/r^2) at spatial infinity) is among the metrics fullfilling stronger asymptotic conditions and supertranslations ambiguities disappear. It is also clear from the result that 14 asymptotic gravitational charges are well defined on the ``Schwarzschildean'' background.Comment: 8 pages, latex, no figure

Phase II study of a short course of weekly high-dose cisplatin combined with long-term oral etoposide in metastatic colorectal cancer.

In a phase I study of weekly administered cisplatin combined with oral etoposide, we observed a partial response in 4 out of 11 patients with metastatic colorectal cancer. Subsequently, we performed a phase II study to investigate the activity of this combination as first-line treatment in this disease. Fourteen patients with metastatic colorectal cancer were enrolled in this study. Treatment consisted of cisplatin, administered in 3% sodium chloride, at a dose of 70 mg m-2 on days 1, 8 and 15 and days 29, 36 and 43 combined with oral etoposide 50 mg absolute dose daily on days 1-15 of both courses. Patients with stable disease or better continued treatment with etoposide 50 mg m-2 orally on days 1-21 every 28 days. A partial response was observed in two patients with liver metastases (14%; 95% confidence limits 2-42%) for 30 and 32 weeks. Five patients had stable disease. Toxicity consisted mainly of anaemia, leucocytopenia, nausea and vomiting. Tinnitus was reported by six patients. The activity of the combination cisplatin-oral etoposide in the schedule is only minimal in metastatic colorectal cancer

Antibodies against p53 are associated with poor prognosis of colorectal cancer.

Mutation of the p53 gene is a common event in colorectal cancer. This alteration can result in cellular accumulation of p53 and may also induce p53 antibodies. Accumulation of p53 in tumour cells has been associated with poor prognosis of colorectal cancer. We tested preoperative sera from 255 patients with colorectal cancer by enzyme-linked immunosorbent assay (ELISA). A total of 70.2% had reactivity that was higher than the 'low' control serum. Employing a cut-off level of 10% of the 'high' control sample, 25.5% of the patients were positive for p53 antibodies. The presence of p53 antibodies correlated with the following prognostic factors: histological differentiation grade, shape of the tumour, and tumour invasion into blood vessels. Patients with p53 antibodies were shown to have decreased survival and decreased disease-free survival. Specifically for patients with cancer stage A and B1 the presence of p53 antibodies selected a subgroup with poor prognosis

A Kinematic Approach To Assessing Environmental Effects: Star-Forming Galaxies in a z~0.9 SpARCS cluster using Spitzer 24um Observations

We present an infrared study of a z=0.872 cluster, SpARCS J161314+564930, with the primary aim of distinguishing the dynamical histories of spectroscopically confirmed star-forming members to assess the role of cluster environment. We utilize deep MIPS imaging and a mass-limited sample of 85 spectroscopic members to identify 16 24um-bright sources within the cluster, and measure their 24um star formation rates (SFRs) down to ~6 Msolar/year. Based on their line-of-sight velocities and stellar ages, MIPS cluster members appear to be an infalling population that was recently accreted from the field with minimal environmental dependency on their star formation. However, we identify a double-sequenced distribution of star-forming galaxies amongst the members, with one branch exhibiting declining specific SFRs with mass. The members along this sub-main sequence contain spectral features suggestive of passive galaxies. Using caustic diagrams, we kinematically identify these galaxies as a virialized and/or backsplash population. Moreover, we find a mix of dynamical histories at all projected radii, indicating that standard definitions of environment (i.e., radius and density) are contaminated with recently accreted interlopers, which could contribute to a lack of environmental trends for star-forming galaxies. A cleaner narrative of their dynamical past begins to unfold when using a proxy for accretion histories through profiles of constant (r/r_200)x(Delta v/sigma_v); galaxies accreted at earlier times possess lower values of (r/r_200)x(Delta v/sigma_v) with minimal contamination from the distinct infalling population. Therefore, adopting a time-averaged definition for density (as traced by accretion histories) rather than an instantaneous density yields a depressed specific SFR within the dynamical cluster core.Comment: 14 pages, 10 figures, 1 table; accepted for publication in Ap

"Peeling property" for linearized gravity in null coordinates

A complete description of the linearized gravitational field on a flat background is given in terms of gauge-independent quasilocal quantities. This is an extension of the results from gr-qc/9801068. Asymptotic spherical quasilocal parameterization of the Weyl field and its relation with Einstein equations is presented. The field equations are equivalent to the wave equation. A generalization for Schwarzschild background is developed and the axial part of gravitational field is fully analyzed. In the case of axial degree of freedom for linearized gravitational field the corresponding generalization of the d'Alembert operator is a Regge-Wheeler equation. Finally, the asymptotics at null infinity is investigated and strong peeling property for axial waves is proved.Comment: 27 page